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FH Calculator - Familial hypercholesterolemia - FH

Familial Hypercholesterolemia (FH) Calculator

The Dutch Lipid Clinic Network (DLCN) criteria, or the Dutch Lipid Score, was first published in 1999. The score was developed by a group of healthcare professionals and researchers in the Netherlands to help identify and diagnose individuals with familial hypercholesterolemia (FH). Since its introduction, the Dutch Lipid Score has become a widely used tool for assessing the likelihood of FH in patients with elevated cholesterol levels.

It is important to note that the Dutch Lipid Score does not provide a “definitive” diagnosis, but rather, it is a tool to help identify individuals who may have FH and require further evaluation, genetic testing, or specialized care. Check our article about Familial Hypercholesterolemia and learn about a stepwise approach to hypercholesterolemia and how to differentiate FH from simple hypercholesterolemia.

FH calculator

 

Familial Hypercholesterolemia (FH) Calculator

 

Family History

Family History
Is there a first degree relative with known premature coronary and/or vascular disease? OR is there a first degree relative with high cholesterol? (first degree includes parents, siblings or children)
Is there a first degree relative with tendon xanthomata and/or arcus cornealis? Or Does the patient have a child aged under 18 with high cholesterol?

Clinical History

Clinical History
Does the patient have premature (men under 55 and women under 65) coronary artery disease (heart attack, past stent or CABG, severe coronary disease on CT scan) ?
Does the patient have premature cerebral or peripheral vascular disease?

Physical Exam

Physical Exam
Does the patient have Arcus Cornealis at <45 years?
Does the patient have Tendon Xanthoma?

LDL-cholesterol (mmol/L)

LDL-cholesterol (mmol/L)
Was the patient on lipid-lowering therapy at time of LDL-cholesterol test?

Genetic Testing

Genetic Testing
Does the patient has mutation in LDLR, APOB or PCSK9 genes?