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Inclisiran (Leqvio), a twice-yearly cholesterol injection that lowers LDL-C
Preventive Cardiology

Inclisiran (Leqvio): Twice-Yearly LDL Cholesterol Injection

How inclisiran silences PCSK9 production in the liver to lower LDL cholesterol by about 50% — the RNA-interference mechanism, the latest ORION and VictORION evidence, safety, and PBS access in Australia.

Dr Reza Moazzeni, MD FRACP·Consultant Cardiologist·Published 28 Aug 2023·Updated Jun 2026

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