Skip to content
Enquiries and Appointments

AHA PREVENT Cardiovascular Risk Calculator

The AHA PREVENT (Predicting Risk of cardiovascular disease EVENTs) equations estimate 10-year risk of atherosclerotic CVD events including heart failure. Unlike traditional calculators, PREVENT incorporates kidney function and metabolic health, reflecting the cardiovascular-kidney-metabolic (CKM) syndrome framework. It is race-free and validated for adults aged 30–79.

SI Units (mmol/L) US Units (mg/dL)
Demographics
Enter age between 30 and 79
Clinical Parameters
Enter value between 1 and 15 mmol/L
Enter value between 0.3 and 5 mmol/L
Enter value between 80 and 250 mmHg
Enter value between 15 and 60
Enter value between 5 and 150
Optional Enhancers
Please complete all required fields
10-Year PREVENT Risk
-- %
--
Estimated 10-year risk of atherosclerotic CVD events
Low
<5%
Borderline
5–7.5%
Intermediate
7.5–20%
High
>20%

How PREVENT Differs From Traditional ASCVD Calculators

The AHA PREVENT equations (Khan SS et al., Circulation 2024) represent a major update to cardiovascular risk prediction. Key differences from the Pooled Cohort Equations include a race-free model (eliminating race as a variable), incorporation of eGFR and BMI as core predictors, optional enhancement with HbA1c and urine albumin-creatinine ratio, a broader age range (30–79 versus 40–79), and inclusion of heart failure as an outcome alongside MI and stroke.

PREVENT was developed from pooled data of over 6 million adults across diverse US cohorts and demonstrates improved calibration compared to the PCE in contemporary populations.

Role of Kidney and Metabolic Risk Factors

Reduced eGFR and albuminuria are independent predictors of cardiovascular events, with risk increasing substantially below eGFR 60 mL/min/1.73m². The inclusion of BMI captures metabolic risk beyond what cholesterol and blood pressure alone reflect. For patients with diabetes, HbA1c provides additional prognostic information, allowing more granular risk stratification within the diabetic population.

The CKM framework recognises that cardiovascular disease, chronic kidney disease, diabetes, and obesity are pathophysiologically interconnected. PREVENT operationalises this concept into a single risk equation, making it particularly useful for patients with metabolic syndrome, CKD, or diabetes where the PCE may underestimate or overestimate risk.

References
  1. Khan SS, Matsushita K, Sang Y, et al. Development and Validation of the AHA PREVENT Equations. Circulation. 2024;149(6):e430–e449.
  2. Arnett DK, Blumenthal RS, Fonarow GC, et al. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease. J Am Coll Cardiol. 2019;74(10):e177–e232.
  3. Ndumele CE, Rangaswami J, Chow SL, et al. Cardiovascular-Kidney-Metabolic Health: AHA Presidential Advisory. Circulation. 2023;148(20):1606–1635.
  4. Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC Guideline on the Management of Blood Cholesterol. Circulation. 2019;139(25):e1082–e1143.
  5. Goff DC Jr, Lloyd-Jones DM, Bennett G, et al. 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk. Circulation. 2014;129(25 Suppl 2):S49–S73.